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Last reviewed: September 2010

Of the more than 54,000 dietary supplement products in the Natural Medicines Comprehensive Database, only about a third have some level of safety and effectiveness that is supported by scientific evidence, according to a review by NMCD experts. And close to 12 percent have been linked to safety concerns or problems with product quality.

Consider the path to market of Go Away Gray, a product that is claimed to "help stop your hair from turning gray." Cathy Beggan, president of the supplement's maker, Rise-N-Shine, based in New Jersey, said that her company has not had to provide product information to the FDA. Nor did it conduct any clinical trials of the supplement, which includes a natural enzyme called catalase, before putting it on sale. Beggan pointed us to a study by European researchers published in the July 2009 issue of the Federation of American Societies for Experimental Biology Journal. The study found that gray hair had lower-than-normal levels of catalase but did not prove that taking that enzyme by mouth would stop hair from turning gray. "We are working on getting an actual clinical trial going because the results have been so amazing, and it would just be good to have some concrete data behind it," Beggan said.