In this report
Overview
Do you really need a pill?
Side effects to watch for
How to spot depression
Depression checklist
The newer antidepressants

TREATMENTS RATED
Find out which therapies work best for depression.

COST-EFFECTIVE DRUGS
Learn more from our Best Buy Drugs report.

March 2009
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The Newer Antidepressants: How Do They Compare?
Generic Name
(Brand name)
Frequency
of Use
per Day
Percentage of
People Who
Stop Taking the
Drug Because
of Side Effects
Cost of Generics Cost of Brand Name Drugs Notes
Bupropion (Wellbutrin)

Two or three 6-8% 75mg tablet: $60

100mg sustained
release tablet: $104

100mg tablet: $66
75mg tablet: $228

100mg sustained
release tablet: $228

100mg tablet: $318
  • Lowest rate of sexual side effects
  • Elevated risk of seizures at high doses
  • Used less often in people with combined anxiety and depression
Citalopram (Celexa)

One 5–9% 20mg tablet: $27

40mg tablet: $38
20mg tablet: $126

40mg tablet: $126
None
Duloxetine (Cymbalta) One or two 3–13% Not available as a generic 60mg coated capsule: $156 None
Escitalopram (Lexapro) One 3–10% Not available as a generic 20mg tablet: $107 None
Fluoxetine (Prozac)

One 7-14% 10mg tablet: $26

20mg capsule: $26
10mg tablet: $196

20mg capsule: $193
  • The only antidepressant, at least to date, that has been approved by the FDA for use in children and teens
Mirtazapine (Remeron) One 10-17% 15mg tablet: $52 15mg tablet: $128
  • Faster onset of action
  • Higher risk of weight gain (usually around 2 to 7 pounds)
Paroxetine (Paxil) One 7-16% 20mg tablet: $36 20mg tablet: $133
  • Higher risk of sexual side effects compared with some other antidepressants
  • Higher risk of sweating
Sertraline (Zoloft) One 7-14% 50mg tablet: $36 50mg tablet: $125
  • Higher rate of diarrhea
Venlafaxine (Effexor) One or two 9–16% 75mg tablet: $138 75mg tablet: $206
  • Substantially higher rate of nausea and vomiting
  • Higher rate of blood pressure problems
 
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